🌿 Top Positive Cannabis Studies (2024–2025)

1. 🧠 PTSD Symptom Relief

A long-term U.S. observational study found that cannabis users with PTSD were 2.6× more likely to no longer meet criteria for PTSD after 1 year.

• Benefits: Reduced nightmares, anxiety, and sleep disruption

• Source: Multidisciplinary Association for Psychedelic Studies (MAPS)

2. 💨 Chronic Pain Reduction

A meta-analysis published in The Lancet Psychiatry concluded that THC and CBD combinations significantly reduce chronic pain, especially in conditions like arthritis, fibromyalgia, and neuropathic pain.

• Result: Pain scores dropped by up to 30%

• Patients also reported reduced opioid use

3. 🎗️ Cancer Symptom Management

A UK-wide registry study of cancer patients using cannabis-based medicinal products (CBMPs) reported:

• Better sleep, less pain, and reduced nausea

• Improved quality of life scores sustained at 6-month follow-up

• Source: Project Twenty21 / Drug Science UK

4. 🧓 Improved Quality of Life in Older Adults

A 2025 Canadian study found that older adults (age 60+) with chronic pain or insomnia who used high-CBD cannabis:

• Reported less anxiety, better sleep, and improved daily functioning

• Reduced use of sleep aids, opioids, and antidepressants

5. ⚖️ Reduced Opioid Use & Overdose Risk

Studies from states with legalized cannabis show:

• Up to 25% fewer opioid overdose deaths

• Patients prescribed medical cannabis used fewer opioids and benzodiazepines

• Source: JAMA Internal Medicine

6. 🧬 Neuroprotective & Anti-inflammatory Potential

Animal studies and early human trials show that CBD and low-dose THC may reduce neuroinflammation, relevant to:

• Alzheimer’s, multiple sclerosis, Parkinson’s

• Some evidence for slowing neurodegeneration and improving cognition

7. 🚼 Epilepsy (CBD – Epidiolex)

The FDA-approved drug Epidiolex (CBD isolate) significantly reduces seizures in children with Lennox-Gastaut and Dravet syndrome.

• Seizure frequency cut by 39–50%

• Well tolerated with minimal sedation compared to traditional anti-epileptics

🧪 Summary Table

Condition	Cannabis Benefit	Type of Study
PTSD	Reduced nightmares, better sleep	Longitudinal / Observational
Chronic pain	Less pain, lower opioid use	Meta-analysis / RCTs
Cancer	Better sleep, appetite, mood	Registry study
Older adults	Improved daily life, sleep, anxiety	Clinical follow-up study
Epilepsy	Dramatic seizure reduction (CBD)	FDA-approved RCTs
Alzheimer's	Reduced inflammation, possible memory aid	Early trials / Animal models